Science of Synthesis is a unique full-text reference work for organic and organometallic chemistry. It provides a critical review of the synthetic methodology from the 1800s to date.
Over 1700 authors contribute with essential reviews as well as detailed experimental procedures. The database gives quick access to detailed methods immediately applicable in the lab. Users familiar with the Houben-Weyl collection will appreciate that this work is still included as a back file.

Recent updates for Science of Synthesis introduced a new section “reference library”. This covers special subjects like -Asymmetric Organocatalysis -Water in Organic Synthesis -Stereoselective Synthesis.