📍 Sala Josefina Castellví

⏰  11.00 h

Biosensing Strategies for Small and Large Molecule Healthcare Indicators

Saccharide sensing using both bio and chemo recognition elements will be presented using redox active/mediated electrochemical transducers. This will include sialic acid redox probes, lactic acid, lactose and glutamate biosensors with the latter extended to protein biomarkers of liver disease (alanine aminotransferase and g-glutamyl transpeptidase). Exploitation of whole cell electrochemical biosensors can aid cytotoxicity studies of engineered nanoparticles. This involved electrochemical assay development of acid phosphatase activity which was transferred to a portable in house designed and fabricated biochip which enabled cell culture, fluidic delivery and detection of redox molecules at screen printed transducers. IC₅₀ values were estimated for model toxins including quantum dots.