Abstract

Peptides are Nature’s scaffolds. They are used to position functional groups in a spatially well-defined manner to facilitate recognition between molecules (e.g. protein-small molecule or protein-protein interactions). We have employed cyclisation as a means to control the conformations of small synthetic peptides and peptidomimetics to enable us to mimic these types of interactions between molecules.  The synthesis, anion binding properties and self-assembly of several classes of cyclic molecules will be presented.